6-[(2S,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-5-fluoropyrimidine-4-carbaldehyde
نویسندگان
چکیده
Voriconazole (VN) is an antifungal drug indicated for the treatment of several fungal infections. Due to its side effects, some works involving late-stage functionalization VN have been reported in literature. Here, we disclose a new derivative, 6-[(2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-5-fluoropyrimidine-4-carbaldehyde (VN-CHO). This compound results from photoredox-catalyzed hydroxymethylation VN, affording hydroxymethylated derivative (VN-CH2OH), followed by oxidation former CH2OH group. VN-CHO was obtained good yield (70% yield) and structure unveiled 1D (1H 13C) 2D (HSQC HMBC) NMR techniques. The introduction formyl group creates very promising site further molecule which originally does not many active sites.
منابع مشابه
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ژورنال
عنوان ژورنال: Molbank
سال: 2023
ISSN: ['1422-8599']
DOI: https://doi.org/10.3390/m1603